Category Archives: Neurology

Study Design Summary: Multicenter trial of 3904 ICU patients who were vented for less than 12 hours at time of randomization, split roughly 50/50 into control group which used other means of sedation such as propofol, benzodiazepines or other sedatives and intervention arm which receiving mainly dexmedetomidine as sedation, with primary outcome of all causeContinue reading “SPICE 3: Does Sedation with Dexmedetomidine Increase Risk of Death at 90 Days”

Study Design Summary: Multinational randomized, placebo controlled study that compared giving TXA vs placebo to patients with TBI and no extracranial bleeding, primary outcome was brain injury related death at 28 days. Notes: This study has many signs pointing towards a biased study. They have many secondary endpoints and changed their definitions of inclusion criteriaContinue reading “CRASH 3: Does TXA Reduce Head Injury Related Deaths in TBI Patients”