Category Archives: Infectious Disease

Study Design Summary: Multinational, placebo controlled trial of 43,448 patient’s who received either a 2 dose COVID-19 vaccine 21 days apart or placebo, with primary outcomes being safety and efficacy against lab confirmed COVID-19 infections. Notes: The placebo and intervention arm were well balanced in their patient demographics, however, 83% of participants were white andContinue reading “COVID-19 Vaccine Pfizer”

Study Design Summary: Multicenter, double-blind trial of 2658 patients with septic shock randomized to either hydrocortisone or placebo for 7 days, with primary outcome all cause mortality at 90 days. Notes: Patients were fairly similar in their baseline characteristics, there was slightly more epinephrine used in the hydrocortisone group, more patients in the control groupContinue reading “ADRENAL: Does Hydrocortisone Reduce Mortality in Septic Shock”

Study Design Summary: Multicenter study of 630 patients split evenly into intervention and control groups, with suspected bacterial infections, looking at 28 and 60 day mortality (non-inferiority analysis) as well as antibiotic exposure between the two groups (superiority analysis). Notes: Patients were eligible if they were not receiving antibiotics prior to enrollment or receiving antibioticsContinue reading “PRORATA: Does Procalcitonin Reduce Antibiotic Exposure and Mortality”

Study Design Summary: Multicenter study in which 700 patients were split to either get 1g IV acetaminophen or not; to be eligible patients had to have a documented temperature ≥38°C with known or suspected infection. Primary outcome was ICU free days from randomization to day 28. End points were discharge from ICU, death, cessation ofContinue reading “HEAT: Does Fever Reduction Lead to More ICU Free Days”