Category Archives: Heme Onc

Study Design Summary: Double-blind, placebo controlled single center trial of 100 hemorrhagic shock patients comparing vasopressin vs placebo with a primary outcome of blood product transfusion requirements. Notes: Significant amounts of vasopressin are released during acute hemorrhage and stores diminish with time. Low levels are associated with catecholamine resistant hypotension and increased venous capacitance. TraumaContinue reading “AVERT-Shock: Does Low Dose Vasopressin Reduce Need for Blood Products in Trauma”

Study Design Summary: Double-blind, placebo controlled, multicenter randomized control trial of 496 patients with spontaneous epistaxis that was persistent despite external pressure and topical vasoconstrictors, then randomized to either topical TXA or placebo. The primary outcome was the need for anterior nasal packing. Notes: The study included patients who presented with spontaneous, non traumatic epistaxis.Continue reading “NoPAC: Does Topical TXA Reduce Need for Anterior Nasal Packing in Spontaneous Epistaxis”

Study Design Summary: Multicenter study examining TAX vs placebo in 4 week all cause mortality in adult trauma patients of both blunt and penetrating trauma. Had some interesting secondary endpoints of need for surgery and blood transfusion units given. Notes: Fairly large study of roughly 20,000 patients, equally balanced TXA and placebo groups. The primaryContinue reading “CRASH 2: Does TXA Reduce All Cause Mortality in Trauma Patients”